Coenzyme Q10 and Cancer
Stephen Sinatra, MD, hypothesized that just as the deficiency of Coenzyme Q10 underlies heart failure, so it too underlies the immune failure that leads to the development of cancer. To a significant extent, cancer may turn out to be a CoQ10 deficiency disease. One of the functions of CoQ10 is protecting DNA from oxidative damage. Another is the enhancement of immune function, and the regulation of aerobic metabolism and energy production. It has been established that 100 mg of CoQ10 per day is the dose required to provide antioxidant protection for LDL cholesterol. Since cancer patients show deficient levels of CoQ10, we need to establish the dose that is likely to prevent cancer.
It is interesting that the most lethal of human cancers, pancreatic cancer, is associated with the greatest CoQ10 depletion. Interestingly, vegetarians are not likely to obtain much CoQ10 in their diet. According to Dr. Sinatra, vegetarians might be in particular need of CoQ10 supplementation, especially as their ability to synthesize it declines with aging. Dr. Sinatra stressed that CoQ10 has produced dramatic tumor-regression results (particularly in metastatic breast cancer) when used together with other treatments, alternative or conventional or both. This reiterates one of the main principles of holistic and anti-aging medicine: Do not seek a single "magic bullet," but use several treatments simultaneously.
Dr. Sinatra warned that dry powdered CoQ10 is poorly absorbed, and it is difficult to achieve therapeutic levels of CoQ10 with it. The gel form in which CoQ10 is combined with an oil is preferable.